When Magnesium Does -- and Does NOT -- Work for Muscle Cramps. | Crampdefense.com



When Magnesium Does -- and Does NOT -- Work for Muscle Cramps.

Magnesium deficiency is a common cause of muscle cramps, including leg cramps. However, simply taking magnesium will NOT necessarily fix muscle cramps every time, for every person. There are several situations where taking magnesium may be ineffective by itself: 

1)Low potassium ("hypokalemia"). Potassium is found in most foods so dietary insufficiency is rare -- however, many diuretics ("water pills") often cause low potassium alongside low magnesium.  Magnesium increases potassium absorption, but this may not be sufficient if a medication is causing large potassium loss.  

2)High potassium ("hyperkalemia"). This is caused by renal insufficiency, or as a side effect of ACE inhibitors, angiotensin blockers, potassium-sparing diuretics, or mineralcorticoid resistance/deficiency. 

3)Soft tissue calcification (not necessarily hypercalcemia). This is triggered by aging and exacerbated by excessive doses of calcium, especially along with Vitamin D, which greatly increases absorption. Excessive calcium is a risk factor for heart attacks and arterial damage, and is best consumed at a moderate level, spread throughout the day. Insufficient Vitamin K and magnesium can also exacerbate calcification. 

4)Low sodium. Low salt diets can cause low sodium levels especially when combined with fluid loss, often due to exercise and/or heat exposure.  

5)Statin use. Statins, prescribed for high cholesterol, are correlated with muscle cramps in patient reports. It is unclear at this time how statins cause cramps. 

6)Beta-2 agonists. These are inhaler medications prescribed for asthma and COPD, which cause cramps very frequently. 

7)Low calcium ("hypocalcemia"). Low serum calcium is known to cause cramps, but it only occurs if you have a very restricted or unusual diet, are grossly Vitamin D deficient, have parathyroid problems, and/or have kidney damage/disease.  

8)Proton-pump inhibitors. "PPIs" decrease your stomach acid, which may decrease the absorption of all minerals, including magnesium.  


If you believe that dietary magnesium deficiency is the factor causing (or exacerbating) your muscle cramps, you can learn more about our unique magnesium product here. 

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May 08, 2019 • Posted by Lydia

I started taking cramp defense and I’ve noticed at night I’m getting very sharp pains only on my left leg and it prevents me from walking. I started taking 2 in the morning, two at noon and 2 at dinner time. Could it possibly be to much. I’m 80 yrs old. The pain is unbearable. Could it be the pills. I did not have this pain on my left leg before.

Nov 24, 2018 • Posted by Brian Scott Adams

Hello to ALL, please tell me if anything has helped…im trying things but little to no effect, life changing.Thanks friends.

Mar 07, 2018 • Posted by john winkler

I started taking the pills 3 months ago. I started with one at bedtime and the cramps stopped. Now the cramps have returned and I have been taking 2 pills daily. What’s up? Does the body develop an immunity to the magnesium? or just flush it out as it does with excess anything?

Nov 10, 2017 • Posted by Jill Reed

Hi! I️ had the gastric sleeve done June 5 2017. But just lately the leg/ foot cramping is so severe I️ have to get up and wAlk it out almost want to go to ER . Very hard to deal with. Help

Nov 04, 2017 • Posted by Lydia laws

I just received my cramp defense pills. I was very excited and started right away. I took as directed…3 early afternoon and 3 later in the evening. But and this is a big BUT, as I was sitting having a snack my foot cramped so bad I couldn’t even get up, almost to tears!! I had thought from what was advertised that the cramps would go away, but it seems they made it worse..So I ask what’s up with that?

Nov 24, 2016 • Posted by Larry D Gaston

The things that you find out after the fact. Ive had muscle spasms for 2 weeks and they have been so bad that I cant stand up straight and the pain is intense. Maybe I need a magnesium supplement since I dont eat right and drink too much milk. Im 60 yrs old.

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